Effect of high intensity interval training (HIIT) on human gut microbiome functional diversity, inflammation and body composition in colorectal cancer survivors

The University of Newcastle - NHMRC CRE in Digestive Health

Research Team: A/Prof Tina Skinner , Dr Marloes Nitert Dekker, Prof David Jenkins, Prof Jeff Coombes and Mr Alexander Boytar

Years: 2021-2022

The human gut microbiome influences tumour growth and spread in individuals with colorectal cancer, as well as indirectly influencing the risks of secondary cancers via inflammation and immune function. Exercise can mediate the burden of colorectal cancer, risk of recurrence and cancer-related mortality.

Exercise interventions have been shown to improve microbiome functional diversity, yet no studies exist in cancer populations. This study will examine changes in the microbiome, and its relationship with changes in body composition and inflammation, in response to high-intensity interval training in colorectal cancer survivors. 

Funding Body: The University of Newcastle CRE

Project members

Associate Professor Tina Skinner

Associate Professor
School of Human Movement and Nutrition Sciences

Professor Jeff Coombes

Professor & Director
School of Human Movement and Nutrition Sciences