The Effects of High Intensity Exercise on Cardiovascular Function in Men with Metastatic Castrate-Resistant Prostate Cancer

This project is a sub study of GAP4-QLD INTense Exercise foR surVivAL among men with Metastatic Castrate-Resistant Prostate Cancer (INTERVAL – MCRPC): A Multicentre, Randomized, Controlled, Phase III Study.

Men with Metastatic Castrate-resistant Prostate Cancer (MCRPC) have elevated oxidative stress, arterial stiffness, vascular dysfunction and sub-optimal cardiac autonomic control. There is also sufficient evidence that these are related. Exercise training decreases oxidative stress, improves vascular structure and function and cardiac autonomic control in a number of patient populations. This has yet to be investigated in men with MCRPC. Therefore, the purpose of this sub-study is to assess the effects of high intensity aerobic and resistance training plus psychosocial support on vascular function and structure, cardiac autonomic function and oxidative stress in this population. The findings from this study will be essential for developing safe and effective lifestyle interventions which have the potential to lead to improved clinical practice for men with this condition.